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Product Description
– Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].
Web ID
– HY-106338
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C44H48O18
References
– [1]Momose I, et al. Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1998 Jan;51(1):21-5.|[2]Daum M, et al. Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem. 2009 Apr 17;10(6):1073-83.|[3]Otoguro K, In vitro antimalarial activities of the microbial metabolites. J Antibiot (Tokyo). 2003 Mar;56(3):322-4.
CAS Number
– 200625-47-4
Molecular Weight
– 864.84
SMILES
– O[C@]1([C@@H]2O[C@]3([H])O[C@@H]([C@@H](O[C@@]4([H])C[C@@](O)([C@H](OC(C5=C(C(C)=CC=C5C)O)=O)[C@H](C)O4)C)CC3)C)[C@](C(C6=C(C(C)=C7C(C(C=C(OC)C7=O)=O)=C6O)C1)=O)(C(/C(C2=O)=C(O)C)=O)O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– ADC Cytotoxin;Bacterial;Parasite
Isoform
– Plasmodium;Traditional Cytotoxic Agents
Pathway
– Antibody-drug Conjugate/ADC Related;Anti-infection
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
