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Polyinosinic-polycytidylic acid
$58 – $570
Products Details
Product Description
– Polyinosinic-polycytidylic acid (Poly (I:C)), a synthetic analog of double-stranded RNA, is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid facilitates tumor regression and has a disruptive effect on the airway epithelial barrier. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses [1][2][3][4][5].
Web ID
– HY-107202
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– (C10H13N4O8P)x.(C9H14N3O8P)x
Citations
– Cancer Med. 2023 Jun 7.|Chem Eng J. 2021 Aug 15;418:129392.|SSRN. 2023 Apr 29.|Virol Sin. 2023 Aug 24;S1995-820X(23)00104-9.|Virol Sin. 2023 May 2;S1995-820X(23)00048-2.|Adv Funct Mater. 29 August 2022.|Liver Int. 2022 Oct 17.|Mol Ther Oncolytics. 25 August 2022.|Phytomedicine. 2021, 153495.|SSRN. 2021 Apr 26.
References
– [1]Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413(6857):732-738. |[2]Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun. 2002;293(5):1364-1369. |[3]Cheng Y, Xu F. Anticancer function of polyinosinic-polycytidylic acid [J]. Cancer biology & therapy, 2010, 10(12): 1219-1223.|[4]Deleidi M, Hallett P J, Koprich J B, et al. The Toll-like receptor-3 agonist polyinosinic: polycytidylic acid triggers nigrostriatal dopaminergic degeneration [J]. Journal of Neuroscience, 2010, 30(48): 16091-16101.|[5]Forte G, Rega A, Morello S, et al. Polyinosinic-polycytidylic acid limits tumor outgrowth in a mouse model of metastatic lung cancer [J]. The Journal of Immunology, 2012, 188(11): 5357-5364.|[6]Rezaee F, Meednu N, Emo J A, et al. Polyinosinic: polycytidylic acid induces protein kinase D–dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells [J]. Journal of Allergy and Clinical Immunology, 2011, 128(6): 1216-1224. e11.|[7]Wang P F, Fang H, Chen J, et al. Polyinosinic-polycytidylic acid has therapeutic effects against cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via TLR3 [J]. The Journal of Immunology, 2014, 192(10): 4783-4794.
CAS Number
– 24939-03-5
Molecular Weight
– N/A
SMILES
– O[C@H]1[C@@H](O[C@H](COP(O)(O)=O)[C@H]1O)N2C3=C(C(NC=N3)=O)N=C2.O[C@H]4[C@H](N5C(N=C(N)C=C5)=O)O[C@H](COP(O)(O)=O)[C@H]4O.[x].[x]
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– H2O : 50 mg/mL (ultrasonic)
Target
– Bcl-2 Family;HSP;Interleukin Related;PKD;Toll-like Receptor (TLR)
Isoform
– Bax;Bcl-2;HSP70;IL-13;IL-17
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
