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Poloxin
$41 – $264
Products Details
Product Description
– Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain, with an IC50 of appr 4.8 μM.
Web ID
– HY-12134
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H19NO3
References
– [1]Lee KS, et al. Pinning down the polo-box domain. Chem Biol. 2008 May;15(5):415-6.|[2]Reindl W, et al. Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Chem Biol. 2008 May;15(5):459-66.|[3]Yuan J, et al. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.
Am J Pathol. 2011 Oct;179(4):2091-9.|[4]Sanhaji M, et al. p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors.
Cell Cycle. 2012 Feb 1;11(3):543-53.
CAS Number
– 321688-88-4
Molecular Weight
– 297.35
Compound Purity
– 98.01
SMILES
– O=C(C(C(C)C)=C/1)C=C(C)C1=N/OC(C2=CC=CC=C2C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 14.29 mg/mL (ultrasonic)
Target
– Polo-like Kinase (PLK)
Isoform
– PLK1;PLK2;PLK3
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
