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Products Details
Product Description
– Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC50 0.21 µM for the Pol I large catalytic subunit RPA194[1].
Web ID
– HY-145840
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H22N4O2
References
– [1]Tony E. Dorado et al. Discovery and Evaluation of Novel Angular Fused Pyridoquinazolinonecarboxamides as RNA Polymerase I Inhibitors. ACS Medicinal Chemistry Letters 2022 13 (4), 608-614
CAS Number
– 2765318-69-0
Molecular Weight
– 386.45
SMILES
– O=C(C1=CC=CN2C(C3=C(C4=C(C=C3)C=CC=C4)N=C12)=O)NCCN5CCCC5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
