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Product Description
– Podofilox-d6 is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II[1][2].
Web ID
– HY-15552S
Shipping
– Room temperature
Molecular Formula
– C22H16D6O8
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75.|[3]Guerrero E, Abad A, Montenegro G, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 Jan 31.|[4]Li M, Zhou L, Yang D, et al. Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complement Altern Med. 2012 Dec 22;12:263.|[5]Prasad V, Chaudhuri AR, Curcio M, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998 Oct;17(7):663-8.|[6]Podophyllotoxin
Molecular Weight
– 420.44
SMILES
– O=C1[C@@]2([C@@]([H])(C3=CC4=C(C=C3[C@H](O)[C@]2(CO1)[H])OCO4)C5=CC(OC([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C(OC)=C5)[H]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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