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PND-1186 (hydrochloride)

$60$388

Products Details

Product Description

– PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis[1].

Web ID

– HY-13917A

Storage Temperature

– 4°C (Powder, sealed storage, away from moisture)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C25H27ClF3N5O3

References

– [1]Tanjoni I, et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther. 2010 May 15;9(10):764-77.

CAS Number

– 1356154-94-3

Molecular Weight

– 537.96

Compound Purity

– 99.38

SMILES

– [H]Cl.O=C(NC)C1=CC=CC=C1NC2=CC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2C(F)(F)F

Clinical Information

– Phase 1

Research Area

– Cancer

Solubility

– DMSO : 200 mg/mL (ultrasonic)|H2O : 20 mg/mL (ultrasonic)

Target

– Apoptosis;FAK

Pathway

– Apoptosis;Protein Tyrosine Kinase/RTK

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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