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PND-1186 (hydrochloride)
$60 – $388
Products Details
Product Description
– PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis[1].
Web ID
– HY-13917A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H27ClF3N5O3
References
– [1]Tanjoni I, et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther. 2010 May 15;9(10):764-77.
CAS Number
– 1356154-94-3
Molecular Weight
– 537.96
Compound Purity
– 99.38
SMILES
– [H]Cl.O=C(NC)C1=CC=CC=C1NC2=CC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2C(F)(F)F
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– DMSO : 200 mg/mL (ultrasonic)|H2O : 20 mg/mL (ultrasonic)
Target
– Apoptosis;FAK
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
