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Products Details
Product Description
– PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research[1][2].
Web ID
– HY-N10558
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C31H44ClN3O7
References
– [1]MartÃn MJ, et al. Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds. J Am Chem Soc. 2013 Jul 10;135(27):10164-71. |[2]Pera B, et al. New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism. ACS Chem Biol. 2013 Sep 20;8(9):2084-94.
CAS Number
– 960210-97-3
Molecular Weight
– 606.15
SMILES
– C/C(Cl)=CC[C@H](OC(N)=O)C/C=CNC([C@H](C(C)(C)C)NC(/C=CC=C/C(C)=C/[C@@H]([C@@]1([H])OC(C(OC)=CC1)=O)C)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
