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Products Details
Product Description
– PLX647 dihydrochloride is an orally active, highly specific dual FMS and KIT kinase inhibitor, with IC50s of 28 and 16 nM, reapectively. PLX647 dihydrochloride shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC50s=91 and 130 nM, respectively)[1].
Web ID
– HY-13838A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H19Cl2F3N4
References
– [1]Zhang C, et al. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5689-94.
CAS Number
– 1779796-38-1
Molecular Weight
– 455.30
SMILES
– FC(F)(F)C1=CC=C(CNC2=CC=C(CC3=CNC4=NC=CC=C43)C=N2)C=C1.Cl.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– c-Fms;c-Kit
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
