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Products Details
Product Description
– Plocabulin (PM060184) is a potent microtubule inhibitor. Plocabulin is a natural product that could be isolated from the marine sponge Lithoplocamia lithistoides. Plocabulin suppresses microtubule shortening and growth. Plocabulin has anticancer activity[1][2].
Web ID
– HY-19922
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C31H45N3O7
References
– [1]MartÃnez-DÃez M, et, al. PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors. Biochem Pharmacol. 2014 Apr 1;88(3):291-302.|[2]Costales-Carrera A, et, al. Plocabulin Displays Strong Cytotoxic Activity in a Personalized Colon Cancer Patient-Derived 3D Organoid Assay. Mar Drugs. 2019 Nov 19;17(11):648.
CAS Number
– 960210-99-5
Molecular Weight
– 571.70
SMILES
– C[C@H]([C@@H]1CC=C(OC)C(O1)=O)/C=C(C)/C=CC=C/C(N[C@H](C(N/C=CC[C@@H](OC(N)=O)C/C=CC)=O)C(C)(C)C)=O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
