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Products Details
Product Description
– Plasma kallikrein-IN-2 (Compound 198) is a potent plasma kallikrein (PKal) inhibitor with an IC50 of 0.1 nM. Plasma kallikrein-IN-2 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research[1].
Web ID
– HY-143476
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C28H24ClF3N8O3
References
– [1]Ram W. Sabnis, et al. Novel Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy. ACS Med Chem Lett. 2022 Mar 4;13(4):528-529.
Molecular Weight
– 612.99
SMILES
– O=C1[C@H]2[C@H](C2)CN1C3=NC=C(C(N4C=C(C=N4)NC(C5=NC(C6=C(C=CC(Cl)=C6F)C(F)F)=CN=C5CO)=O)C)N=C3C
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Ser/Thr Protease
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
