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PKR-IN-C51
$160 – $1,300
Products Details
Product Description
– PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages[1].
Web ID
– HY-118131
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H21N5
References
– [1]Ruslana Bryk, et al. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14.
CAS Number
– 1314594-23-4
Molecular Weight
– 367.45
Compound Purity
– 99.93
SMILES
– CC(NC1=C2C=CC=C1)=C2C3=NC(NCCC4=CNC5=C4C=CC=C5)=NC=C3
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Ser/Thr Protease
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
