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Products Details
Product Description
– PKI-166 hydrochloride is a potent, selective and orally active EGFR tyrosine kinase inhibitor, with an IC50 of 0.7 nM[1].
Web ID
– HY-110328
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H19ClN4O
References
– [1]Bruns CJ, et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 2000 Jun 1;60(11):2926-35.
CAS Number
– 2230253-82-2
Molecular Weight
– 366.84
SMILES
– OC1=CC=C(C2=CC3=C(N=CN=C3N2)N[C@H](C)C4=CC=CC=C4)C=C1.Cl[H]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
