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Products Details
Product Description
– PKF050-638 is a potent and selective inhibitor of HIV-1 Rev (IC50=0.04 μM). PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction[1].
Web ID
– HY-114597
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H13ClN4O2
References
– [1]Daelemans D, et al. A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14440-5. Epub 2002 Oct 9.
CAS Number
– 528893-52-9
Molecular Weight
– 292.72
SMILES
– O=C(OCC)/C=CN1N=CN=C1C2=CC(Cl)=CC=C2N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CRM1;HIV
Isoform
– HIV-1
Pathway
– Anti-infection;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
