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Products Details
Product Description
– PKF050-638 is a potent and selective inhibitor of HIV-1 Rev (IC50=0.04 μM). PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction[1].
Web ID
– HY-114597
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H13ClN4O2
References
– [1]Daelemans D, et al. A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14440-5. Epub 2002 Oct 9.
CAS Number
– 528893-52-9
Molecular Weight
– 292.72
SMILES
– O=C(OCC)/C=CN1N=CN=C1C2=CC(Cl)=CC=C2N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CRM1;HIV
Isoform
– HIV-1
Pathway
– Anti-infection;Membrane Transporter/Ion Channel
Product type
– Reference compound
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