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Products Details
Product Description
– PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively[1].
Web ID
– HY-122857
Shipping
– Room temperature
Molecular Formula
– C25H22FN5O
References
– [1]Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61(10):4386-4396.
CAS Number
– 2230052-97-6
Molecular Weight
– 427.47
SMILES
– COC1=CC2=C(CNC(CF)C2)C=C1C3=C4C=C(C5=C6C(NC=C6)=NC=C5)C=CN4N=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PKC
Isoform
– PKCα;PKCε;PKCι
Pathway
– Epigenetics;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
