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Product Description
– Piribedil dihydrochloride is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil dihydrochloride is also a α2-adrenoceptors antagonist. Piribedil dihydrochloride can inhibit MLL1 methyltransferase activity (EC50: 0.18 μM). Piribedil dihydrochloride has the potential for the research of parkinson’s disease, circulatory disorders, cancers[1][2][3][4].
Web ID
– HY-12707A
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C16H20Cl2N4O2
References
– [1]Sweet RD, et al. Piribedil, a dopamine agonist, in Parkinson’s disease. Clin Pharmacol Ther. 1974 Dec;16(6):1077-82. |[2]Gerlach M, et al. The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson’s disease: differential role of α(2) adrenergic mechanisms. J Neural Transm (Vienna). 2013 Jan;120(1):31-6. |[3]Smith LA, Tet al. Repeated administration of piribedil induces less dyskinesia than L-dopa in MPTP-treated common marmosets: a behavioural and biochemical investigation. Mov Disord. 2002 Sep;17(5):887-901.|[4]Xiong Zhang, et al. Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis. Cancer Lett. 2018 Sep 1;431:150-160.
CAS Number
– 1451048-94-4
Molecular Weight
– 371.26
SMILES
– C1(N2CCN(CC3=CC=C(OCO4)C4=C3)CC2)=NC=CC=N1.Cl.Cl
Clinical Information
– Launched
Research Area
– Cancer; Endocrinology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor;Dopamine Receptor;Histone Methyltransferase
Isoform
– D2 Receptor;D3 Receptor;α adrenergic receptor
Pathway
– Epigenetics;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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