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Pioglitazone
$46 – $132
Products Details
Product Description
– Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research[2][3][4].
Web ID
– HY-13956
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H20N2O3S
Citations
– Acta Pharmacol Sin. 2021 Jan;42(1):160-170.|Am J Physiol Heart Circ Physiol. 2021 Apr 9.|Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F137-F151.|Biochem Eng J. 2021, 108104.|BMC Complement Med Ther. 2022 Jul 1;22(1):176.|Br J Pharmacol. 2021 Jun;178(11):2305-2323.|Cancer Res. 2022 Apr 15;82(8):1503-1517.|Cell Metab. 2021 Mar 2;33(3):581-597.e9.|Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9.|Food Chem Toxicol. 2021 Apr 6;112183.|Gut Microbes. 2022, 14(1): 2139978.|Heliyon. 2023 Apr 1.|Immunology. 2023 Jan 28.|Immunopharmacol Immunotoxicol. 2021 Aug 27;1-9.|J Steroid Biochem Mol Biol. 2023 Feb 1;229:106265.|Med Sci Monit. 2019 Nov 13;25:8544-8553.|Nutr Metab (Lond). 2019 Mar 5;16:17. |Oxid Med Cell Longev. 2022.|Research Square Preprint. 2021 Mar.|SSRN. 2023 May 30.|Inflammation. 2020 Apr;43(2):568-578.|Int J Oncol. 2018 Aug;53(2):551-566.|J Diabetes Res. 2019 Feb 3;2019:5245063.|Mol Med Rep. 2019 Jan;19(1):400-406.
References
– [1]Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve|[2]Puddu A, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84.|[3]Kubota N, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281(13):8748-55.|[4]Elrashidy RA, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):324-33.
CAS Number
– 111025-46-8
Molecular Weight
– 356.44
Compound Purity
– 99.66
SMILES
– O=C(N1)SC(CC2=CC=C(OCCC3=NC=C(CC)C=C3)C=C2)C1=O
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cancer
Solubility
– DMSO : 40 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Ferroptosis;PPAR
Isoform
– PPARα;PPARβ/δ;PPARγ
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
