Products Details

Product Description

– PIM1-IN-7 (compound 6c) is a potent PIM-1 inhibitor, with an IC50 of 0.67 μM. PIM1-IN-7 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC50 values of 42.9 and 7.68 μM, respectively[1].

Web ID

– HY-147921

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C23H23N5O

References

– [1]Philoppes JN, et al. New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics. Bioorg Chem. 2020 Jul;100:103944.

CAS Number

– 2439168-72-4

Molecular Weight

– 385.46

SMILES

– O=C(C1=C2N=C(C)C=C(C)N2N=C1NC3=CC=CC=C3)NC4=C(C)C=CC=C4C

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Pim

Isoform

– PIM1

Pathway

– JAK/STAT Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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