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Products Details
Product Description
– PI3Kα-IN-13 (Compound 18a) is a PI3Kα inhibitor (IC50: 2.5 nM). PI3Kα-IN-13 induces tumor cell apoptosis. PI3Kα-IN-13 inhibits cancer cell proliferation with IC50s of 0.75 μM (MCF-7), 3.79 μM (HCT-116), 13.71 μM (MDA-MB-231), 9.85 μM (SW620), respectively. PI3Kα-IN-13 inhibits tumor cell colony formation, migration and invasion[1].
Web ID
– HY-156018
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H19N5O3
References
– [1]Zheng XM, et al. Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs. Eur J Med Chem. 2023 Nov 15;260:115754.
CAS Number
– 2955529-67-4
Molecular Weight
– 389.41
SMILES
– NC1=NC2=CC(C3=CC=C4N=CC(N5C[C@H](OCCO6)[C@H]6C5)=NC4=C3)=CC=C2O1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PI3K
Isoform
– PI3Kα
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
