Products Details

Product Description

– PI3K/mTOR Inhibitor-9 (Compound 1) is a potent mTOR and PI3K inhibitor with IC50 values of 38 nM, 6.6 μM, 6.6 μM and 0.8 μM against mTOR (phospho-S6 cellular assay), PI3Kα, PI3Kγ and PI3Kδ, respectively[1].

Web ID

– HY-147285

Shipping

– Room temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C23H27N7O2

References

– [1]Bonazzi S, et al. Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders. J Med Chem. 2020 Feb 13;63(3):1068-1083.

CAS Number

– 1392421-71-4

Molecular Weight

– 433.51

SMILES

– C[C@H]1N(CCOC1)C2=C3C(N=C(C4=C5C(NC=C5)=CC=C4)N3)=NC(N6[C@H](COCC6)C)=N2

Clinical Information

– No Development Reported

Research Area

– Neurological Disease

Solubility

– 10 mM in DMSO

Target

– mTOR;PI3K

Isoform

– mTOR;PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ

Pathway

– PI3K/Akt/mTOR

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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