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Products Details
Product Description
– PI3K/mTOR Inhibitor-12 is a potent, orally active and selective PI3K/mTOR inhibitor with IC50 values of 0.06 nM and 3.12 nM for PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-12 has antitumor activity. PI3K/mTOR Inhibitor-12 has lower liver toxicity[1].
Web ID
– HY-152238
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H27F2N9O4S
References
– [1]Li C, et, al. Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors. Eur J Med Chem. 2022 Dec 20;247:115030.
CAS Number
– 2891692-83-2
Molecular Weight
– 611.62
SMILES
– O=S(C1=CC=C(F)C=C1F)(NC2=CC(C3=NN4C(C=C3)=NC=C4C5=CN(CCCN6CCOCC6)N=N5)=CN=C2OC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– mTOR;PI3K
Isoform
– mTOR;PI3Kα
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
