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PI3K-IN-48
Products Details
Product Description
– PI3K-IN-48 is a PI3K inhibitor with IC50 value of 1.55 ± 0.18 μM for A549 cells. PI3K-IN-48 can induce G0/G1 phase arrest, cell apoptosis, and down-regulate expression of p-PI3K and p-Akt. PI3K-IN-48 can be used for human lung cancers diseases research[1].
Web ID
– HY-156080
Shipping
– Room temperature
Molecular Formula
– C25H21FN2O4
References
– [1]Wu W, et al. Design, synthesis and antitumor effects of novel benzimidazole derivatives as PI3K inhibitors. Bioorg Med Chem Lett. 2023 Sep 7;95:129469.
Molecular Weight
– 432.44
SMILES
– COC1=CC(OC)=C(C=C1C2=NC3=CC(OC)=C(C=C3N2)C#CC4=C(C=CC=C4)F)OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt;PI3K
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.