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PI3K-IN-41
Products Details
Product Description
– PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect[1].
Web ID
– HY-155730
Shipping
– Room temperature
Molecular Formula
– C45H39F2N5O12S
References
– [1]Tian H, et al. Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release. ACS Med Chem Lett. 2023 Jul 24;14(8):1100-1107.
Molecular Weight
– 911.88
SMILES
– COC1=CC(COC2=CC3=C(C=C(C(O3)=O)CN(S(C4=C(C=C(C=C4)F)F)(=O)=O)C5=C(N=CC(C6=CC7=C(N=CN=C7C(OC8CCOCC8)=C6)C)=C5)OC)C=C2)=C(C=C1OC)[N+]([O-])=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– PI3K
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
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