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Products Details
Product Description
– PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].
Web ID
– HY-144450
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H22ClN7O3S
References
– [1]Tian C, et al. Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity. Bioorg Med Chem Lett. 2021, 48:128271.
CAS Number
– 2768005-77-0
Molecular Weight
– 560.03
SMILES
– O=S(NC1=CC(C2=CC=C3N=NC=C(C3=C2)C4=CN=C(N=C4)N5CCOCC5)=CN=C1Cl)(C6=CC=CC=C6)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt;PI3K
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
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