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Product Description
– PI3K-IN-28 (Compound 6c) is a potent inhibitor of PI3K. PI3K-IN-28 displays the most potent activity with lower toxic effects on MCF-10a. PI3K-IN-28 displays half-maximal inhibitory concentration (IC50, μM) values of 5.8, 2.3, and 7.9. PI3K-IN-28 is the most potent one with a selectivity index (SI) of 39 and is considered as a latent lead for further optimization of anticancer agents[1].
Web ID
– HY-145432
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H16F9N3O3S2
References
– [1]Tantawy AH, et al. Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Fluorinated Candidates as PI3K Inhibitors: Targeting Fluorophilic Binding Sites. J Med Chem. 2021 Dec 9;64(23):17468-17485.
CAS Number
– 2747100-02-1
Molecular Weight
– 653.54
SMILES
– O=S(OC1=CC=C(C=C1)/C=N/N=C2SC=C(N2C3=CC=CC=C3)C4=CC=CC=C4)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PI3K
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
