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Products Details
Product Description
– PI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC50=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC50=13/190 nM, respectively)[1].
Web ID
– HY-101517
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H29F2N3O5
References
– [1]Barlaam B, et al. Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours. Bioorg Med Chem Lett. 2017 May 1;27(9):1949-1954.
CAS Number
– 1403458-28-5
Molecular Weight
– 525.54
SMILES
– O=C1C=C(N2CCOCC2)OC3=C([C@@H]4N(C5=CC(F)=CC(F)=C5)CCC4)C=C(C(N6CCOCC6)=O)C=C13
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PI3K
Isoform
– PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
