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Products Details
Product Description
– PI3Kβ-IN-1 (compound (P)-14) is a selective and orally active PI3Kβ inhibitor, with an IC50 of 2 nM[1].
Web ID
– HY-145338
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H14F2N8
References
– [1]Perreault S, et al. Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif. ACS Med Chem Lett. 2020 Apr 13;11(6):1236-1243.
CAS Number
– 2215098-77-2
Molecular Weight
– 464.43
SMILES
– CC([N@](C1=C2)[C@]3=CC=NC4=C(F)C=CC(F)=C34)=NC1=C(C5=NN=CN5)C=C2C6=CC=NC(C#N)=C6
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PI3K
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
