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Products Details
Product Description
– PI3Kα-IN-8 (Compound 9g) is a selective PI3Kα inhibitor with an IC50 of 0.012 μM. PI3Kα-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis[1].
Web ID
– HY-147983
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H27BrN4O2
References
– [1]Yang YQ, et al. Synthesis and anticancer evaluation of novel 1H-benzo[d]imidazole derivatives of dehydroabietic acid as PI3Kα inhibitors. Bioorg Chem. 2020 Jul;100:103845.
Molecular Weight
– 507.42
SMILES
– O=C([C@]1(C)CCC[C@]2(C)C3=CC(Br)=C4NC(NC5=CC=C(C#N)C=C5)=NC4=C3CCC12)OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PI3K;Reactive Oxygen Species
Isoform
– PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR
Product type
– Reference compound
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