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Products Details
Product Description
– PI3Kα-IN-13 (Compound 18a) is a PI3Kα inhibitor (IC50: 2.5 nM). PI3Kα-IN-13 induces tumor cell apoptosis. PI3Kα-IN-13 inhibits cancer cell proliferation with IC50s of 0.75 μM (MCF-7), 3.79 μM (HCT-116), 13.71 μM (MDA-MB-231), 9.85 μM (SW620), respectively. PI3Kα-IN-13 inhibits tumor cell colony formation, migration and invasion[1].
Web ID
– HY-156018
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H19N5O3
References
– [1]Zheng XM, et al. Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs. Eur J Med Chem. 2023 Nov 15;260:115754.
CAS Number
– 2955529-67-4
Molecular Weight
– 389.41
SMILES
– NC1=NC2=CC(C3=CC=C4N=CC(N5C[C@H](OCCO6)[C@H]6C5)=NC4=C3)=CC=C2O1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PI3K
Isoform
– PI3Kα
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
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