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Products Details
Product Description
– PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity[1]. PI3Kγ inhibitor 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-153703
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C31H25N9O2
References
– [1]HeJun Lv, et al. Alkyne derivative, preparation method for same, and uses thereof. WO2021004421A1.
CAS Number
– 2575863-25-9
Molecular Weight
– 555.59
SMILES
– O=C1C2=C(C#CC3=CN(C4CC4)N=C3)C=CC=C2N=C(N1C5=CC=CC=C5)[C@H](C)NC(C6=C7N(C=CC=N7)N=C6N)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PI3K
Isoform
– PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
