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Products Details
Product Description
– PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and induces apoptosis[1].
Web ID
– HY-147767
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H15IN2OS
References
– [1]Singh D, et al. Synthesis of 3-N-/O-/S-methyl-imidazo[1,2-a] pyridine derivatives for caspase-3 mediated apoptosis induced anticancer activity.
CAS Number
– 2272894-14-9
Molecular Weight
– 410.27
SMILES
– COC1=CC=C(C=C1)SCC2=C(N=C3C=CC(C)=CN32)I
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PI3K;Reactive Oxygen Species
Isoform
– PI3Kα
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR
Product type
– Reference compound
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