Download Files:
Products Details
Product Description
– Phortress free base (NSC 710305) is a P450 CYP1A1-activated antitumor prodrug with antitumor activity[1]. Phortress free base leads to DNA damage and cell cycle arrest[2].
Web ID
– HY-128920
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H23FN4OS
References
– [1]Behrsing HP, et al. In vitro exposure of precision-cut lung slices to 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride (NSC 710305, Phortress) increases inflammatory cytokine content and tissue damage. Toxicol Sci. 2013 Feb;131(2):470-9.|[2]Trapani V, et al. DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells. Br J Cancer. 2003 Feb 24;88(4):599-605.
CAS Number
– 741241-36-1
Molecular Weight
– 386.49
SMILES
– O=C(NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C)[C@@H](N)CCCCN
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450
Isoform
– CYP1
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
