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Products Details
Product Description
– Phenytoin-15N2,13C is the 13C and 15N labeled Phenytoin[1]. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3].
Web ID
– HY-B0448S1
Shipping
– Room temperature
Molecular Formula
– C14 13CH12 15N2O2
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5(7): p. 553-64.|[3]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.|[4]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51(5): p. 1379-87.|[5]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 2714(1):13.
CAS Number
– 78213-26-0
Molecular Weight
– 255.25
SMILES
– O=C1C(C2=CC=CC=C2)(C3=CC=CC=C3)[15NH][13C]([15NH]1)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Sodium Channel;Virus Protease
Pathway
– Anti-infection;Membrane Transporter/Ion Channel
Product type
– Isotope-Labeled Compounds
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