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Phenytoin
$55 – $106
Products Details
Product Description
– Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].
Web ID
– HY-B0448
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C15H12N2O2
Citations
– Oxid Med Cell Longev. 2022 Mar 28;2022:8538296.|Regen Ther. 2023 Dec, 24, 201-210.|Int Immunopharmacol. 2023 Jan 11;115:109706.|University of Glasgow. School of Cancer Sciences.
References
– [1]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5(7): p. 553-64.|[2]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.|[3]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51(5): p. 1379-87.|[4]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14(1):13.
CAS Number
– 57-41-0
Molecular Weight
– 252.27
Compound Purity
– 99.90
SMILES
– O=C1NC(C(C2=CC=CC=C2)(C3=CC=CC=C3)N1)=O
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Sodium Channel;Virus Protease
Pathway
– Anti-infection;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
