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Product Description
– Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM)[1][2][3].
Web ID
– HY-B1733
Shipping
– Room temperature
Molecular Formula
– C17H21NO
References
– [1]Justin B.Hoekstra. Pharmacological Properties of a New Antihistaminic Agent, Phenyltoloxamine (Bristamin). Journal of the American Pharmaceutical Association (Scientific ed.). 1953, 42 (10), 587-593. |[2]Brandes LJ, et al. Evidence that the antiestrogen binding site is a histamine or histamine-like receptor. Biochem Biophys Res Commun. 1985 Jan 31;126(2):905-10. |[3]Youyi Peng, et al. Comprehensive 3D-QSAR Model Predicts Binding Affinity of Structurally Diverse Sigma 1 Receptor Ligands. J Chem Inf Model. 2019 Jan 28;59(1):486-497. |[4]Sellers, et al. Use of inhibitors of CYP2D6 enzyme for the prevention of drug abuse. Patent, US6124282.
CAS Number
– 92-12-6
Molecular Weight
– 255.35
SMILES
– CN(C)CCOC1=CC=CC=C1CC2=CC=CC=C2
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450;Histamine Receptor;Sigma Receptor
Isoform
– Sigma 1 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
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