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Phenoxodiol
$180 – $1,500
Products Details
Product Description
– Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2].
Web ID
– HY-13721
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H12O3
References
– [1]Kamsteeg M, et al. Phenoxodiol–an isoflavone analog–induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22(17):2611-20.|[2]Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110.
CAS Number
– 81267-65-4
Molecular Weight
– 240.25
Compound Purity
– 99.76
SMILES
– OC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic)
Target
– Apoptosis;Caspase;Topoisomerase
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
