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Product Description
– Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].
Web ID
– HY-16397
Shipping
– Room temperature
Molecular Formula
– C10H15N5
References
– [1]Yendapally R, et al. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020 Jun;81(4):390-401.|[2]GarcÃa Rubiño ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20(13):3316.
CAS Number
– 114-86-3
Molecular Weight
– 205.26
SMILES
– NC(NC(NCCC1=CC=CC=C1)=N)=N
Clinical Information
– Launched
Research Area
– Cancer; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– AMPK;Apoptosis;Mitochondrial Metabolism
Pathway
– Apoptosis;Epigenetics;Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
