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PHA-767491 (hydrochloride)

$55$286

Products Details

Product Description

– PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively.

Web ID

– HY-13461A

Storage Temperature

– 4°C (Powder, sealed storage, away from moisture)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C12H12ClN3O

Citations

– Autophagy. 2021 Dec 10;1-19.|Sci Rep. 2021 Mar 8;11(1):5374.|Acta Pharmacol Sin. 2021 Jun 29.

References

– [1]Montagnoli A, et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4(6):357-65.|[2]Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300.|[3]Li W, et al. Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. Curr Cancer Drug Targets. 2015;15(3):196-204.|[4]Erbayraktar Z, et al. Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness. Cancer Cell Int. 2016 Nov 18;16:88.

CAS Number

– 942425-68-5

Molecular Weight

– 249.70

Compound Purity

– 98.06

SMILES

– O=C1C2=C(NC(C3=CC=NC=C3)=C2)CCN1.[H]Cl

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 17.33 mg/mL (ultrasonic;warming)|H2O : 50 mg/mL (ultrasonic)

Target

– Apoptosis;CDK

Isoform

– CDK1;CDK2;CDK5;CDK9

Pathway

– Apoptosis;Cell Cycle/DNA Damage

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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