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Products Details
Product Description
– PFI-6 is a non-cytotoxic and selective MLLT1/3 probe targeting the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). PFI-6 shows IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 can serve as a molecular tool to explore the role of MLLT1/3 in various diseases and related genome validation studies[1].
Web ID
– HY-155412
Shipping
– Room temperature
Molecular Formula
– C22H21N3O4
References
– [1]Raux B, et al. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg Med Chem Lett. 2023 Nov 7:129546.
CAS Number
– 2675452-91-0
Molecular Weight
– 391.42
SMILES
– O=C(N(C)C)C1=CC=C(C2=CC(C(N[C@H]3C(C=CC=C4)=C4CC3)=O)=NO2)C=C1O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Biochemical Assay Reagents
Pathway
– Others
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
