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PF-562271 (besylate)
$158 – $495
Products Details
Product Description
– PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase, with an IC50 of 1.5 nM and 13 nM, respectively[1].
Web ID
– HY-10458
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H26F3N7O6S2
Citations
– Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.|Anticancer Drugs. 2023 Jul 14.|Cancer Res. 2013 May 1;73(9):2873-83.|Carbohydr Polym. 2024 Feb 15, 326, 121637.|Cell Death Dis. 2022 Sep 10;13(9):783.|Cell Death Dis. 2023 Feb 24;14(2):157.|Cell Discov. 2022 Sep 6;8(1):84.|Cell Rep. 2023 Oct 5;42(10):113213.|Clin Cancer Res. 2019 Jul 15;25(14):4552-4566.|Environ Toxicol Pharmacol. 2023 Oct 20:104301.|Harvard Medical School LINCS LIBRARY|Int J Cancer. 2015 Oct 1;137(7):1549-59.|J Nat Med. 2020 Sep;74(4):732-740.|Life Sci. 2021 Jan 25;119112.|Practical Oncology Journal. 2015, 29(5): 444-449.|Research Square Preprint. 2021 Dec.|Research Square Preprint. 2023 May 23.|Sci Rep. 2018 May 8;8(1):7228.Â
References
– [1]Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68(6), 1935-1944.|[2]Lim ST, et al. FERM control of FAK function: implications for cancer therapy. Cell Cycle, 2008, 7(15), 2306-2314.|[3]Canel M, et al. Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res, 2010, 70(22), 9413-9422.
CAS Number
– 939791-38-5
Molecular Weight
– 665.66
Compound Purity
– 99.17
SMILES
– CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O.O=S(C5=CC=CC=C5)(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 21.4 mg/mL (ultrasonic;warming)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– FAK;Pyk2
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
