PF-4708671

$58$374

Products Details

Product Description

– PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM.

Web ID

– HY-15773

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C19H21F3N6

References

– [1]Pearce LR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55.|[2]Zhang Y, et al. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. Mol Cancer Ther. 2015 Mar;14(3):799-809.

CAS Number

– 1255517-76-0

Molecular Weight

– 390.41

Compound Purity

– 99.85

SMILES

– FC(C1=CC=C2N=C(CN3CCN(C4=NC=NC=C4CC)CC3)NC2=C1)(F)F

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 33.33 mg/mL (ultrasonic)

Target

– Autophagy;Ribosomal S6 Kinase (RSK)

Isoform

– p70S6K

Pathway

– Autophagy;MAPK/ERK Pathway

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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