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PF-429242
SKU
HY-13447-Get quote
Category Reference compound
Tags Anti-infection;Metabolic Enzyme/Protease, Fatty Acid Synthase (FASN);Virus Protease, Infection; Metabolic Disease
Products Details
Product Description
– PF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1].
Web ID
– HY-13447
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C25H35N3O2
References
– [1]Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther. 2008 Sep;326(3):801-8.|[2]Uchida L, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016 Feb 10;8(2). pii: E46.|[3]Urata S, et al. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011 Jan;85(2):795-803.
CAS Number
– 947303-87-9
Molecular Weight
– 409.56
SMILES
– O=C(N(CCC1=CC=CC=C1OC)[C@H]2CNCC2)C3=CC=C(CN(CC)CC)C=C3
Clinical Information
– No Development Reported
Research Area
– Infection; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Fatty Acid Synthase (FASN);Virus Protease
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
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