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PF-07220060
$142 – $2,250
Products Details
Product Description
– PF-07220060 (CDK4/6-IN-6; example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].
Web ID
– HY-139450
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H27ClFN5O3
References
– [1]Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.
CAS Number
– 2380321-51-5
Molecular Weight
– 463.93
Compound Purity
– 99.87
SMILES
– CC(N1C2=CC(C3=NC(N[C@H]4[C@@H](COCC4)O)=NC=C3Cl)=CC(F)=C2N=C1C(C)(O)C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– CDK
Isoform
– CDK4;CDK6
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
