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Products Details
Product Description
– PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research[1][2].
Web ID
– HY-139293
Shipping
– Room temperature
Molecular Formula
– C19H16FN5O2
References
– [1]Gopalsamy A, et al. PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease. J Med Chem. 2021 Jan 14;64(1):326-342.|[2]Aaron Baldwin, et al. Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture. Org. Process Res. Dev. 2023.
CAS Number
– 2435610-93-6
Molecular Weight
– 365.36
SMILES
– NC1=NC(C=CC(F)=C2)=C2C=C1O[C@H](C3=C(N4C=CC=N4)C=CC(N3)=O)C
Clinical Information
– Phase 1
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Others
Pathway
– Others
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
