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PF-06761281
$100 – $700
Products Details
Product Description
– PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 µM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively[1].
Web ID
– HY-120669
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C13H17NO6
References
– [1]Huard K, et al. Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem. 2016 Feb 11;59(3):1165-75.
CAS Number
– 1854061-19-0
Molecular Weight
– 283.28
Compound Purity
– 99.32
SMILES
– O=C(O)[C@](CCC1=CC(C)=CN=C1OC)(O)CC(O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– H2O : ≥ 50 mg/mL
Target
– Sodium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
