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PF-06305591
$130 – $1,280
Products Details
Product Description
– PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile[1].
Web ID
– HY-114301
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C15H22N4O
References
– [1]Brown AD, et al. The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain. Bioorg Med Chem. 2019 Jan 1;27(1):230-239.
CAS Number
– 1449473-97-5
Molecular Weight
– 274.36
Compound Purity
– 99.92
SMILES
– CC(C)(C)C1=CC=C(NC([C@H]([C@@H](C)C(N)=O)N)=N2)C2=C1
Clinical Information
– Phase 1
Research Area
– Neurological Disease
Solubility
– DMSO : 140 mg/mL (ultrasonic)
Target
– Sodium Channel
Isoform
– Nav1.8
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
