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Products Details
Product Description
– Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].
Web ID
– HY-B0537
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H24N4O2
References
– [1]Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64.|[2]Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.|[3]Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.|[4]David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49.
CAS Number
– 100-33-4
Molecular Weight
– 340.42
SMILES
– N=C(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N
Clinical Information
– Launched
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial;Fungal;Parasite;Phosphatase
Isoform
– Leishmania;Trypanosoma
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
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