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Products Details
Product Description
– Pecavaptan is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema[1].
Web ID
– HY-109133
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C22H19Cl2F3N6O3
References
– [1]Mondritzki T, et al. Cardiac output improvement by pecavaptan: a novel dual-acting vasopressin V1a/V2 receptor antagonist in experimental heart failure. Eur J Heart Fail. 2021 May;23(5):743-750.
CAS Number
– 1914998-56-3
Molecular Weight
– 543.33
SMILES
– O[C@H](C(F)(F)F)CN1C(C2=CC=C(Cl)C=C2)=NN(CC3=NN(C4=CC(Cl)=CC=C4)C([C@@H](O)C)=N3)C1=O
Clinical Information
– Phase 2
Research Area
– Metabolic Disease; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Vasopressin Receptor
Isoform
– V1a Receptor ;V2 ReceptorÂ
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
