Download Files:
Web ID
– HY-12294
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C17H17BrN3O5P
Citations
– J Clin Invest. 2019 Sep 3;129(9):3864-3876.|Neuroscience. 2018 Nov 1;391:1-12.|Am J Hypertens. 2021 Apr 15;hpab047.|Cells. 2023 Apr 22, 12(9), 1212.|Front Neurosci. 2021; 15: 703044.
References
– [1]Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.|[2]Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91.|[3]Yu X, et al. Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation. Neuroscience. 2018 Nov 1;391:1-12.
CAS Number
– 459836-30-7
Molecular Weight
– 454.21
SMILES
– O=C1C(NC2=C(C(C(P(O)(O)=O)N[C@H](C3=CC=C(Br)C=C3)C)=CC=C2)N1)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– iGluR
Isoform
– NMDA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
