Products Details

Product Description

– PDHK-IN-5 (Compound 19) is a potent inhibitor of PDHK with IC50s of 0.006 and 0.0329 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-5 has the potential for the research of cancer diseases[1].

Web ID

– HY-146554

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C30H31N5O2

References

– [1]Bessho Y, et al. Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem. 2021 Dec 15;52:116514

Molecular Weight

– 493.60

SMILES

– CC1=NC2=C(C3=CC=CC(C4CC4)=C3N2)C=C1C5=NN=C(O5)C(C(C)C)CC(NCC6=CC=CC=C6)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– PDHK

Pathway

– Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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